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本研究结果显示,两组患者的总有效率分别为56.7%和81.8%,其中CR率分别为6.7%和27.3%,显示三维适形放疗联合多西他赛近期疗效明显优于序贯放化疗。两组1、2年生存率分别63.5% (19/30)、79.4% (26/33)和40.0%(12/30)、54.4% (18/33),三维适形放疗联合多西他赛组比序贯放化疗组高出十多个百分点,中位生存期亦比其高出7.5个月,虽无统计学意义,仍显示提高局部控制可使患者的长期生存获益。研究结果因观察时间有限,远期疗效和并发症有待进一步随访。
综上所述, TP方案联合三维适形放疗治疗晚期非小细胞肺癌有比较好的疗效及安全性,可延长生存期,急性毒副反应可耐受。因此TP方案联合放疗治疗晚期非小细胞肺癌是一种积极有效的措施。
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