贺智敏，男，医学博士，广州医学院教授，博士生导师；现任广州医学院肿瘤研究所所长兼附属肿瘤医院中心实验室主任。1982年毕业于湖南医学院医疗系，先后获学士、硕士、博士学位；1998年2007年间作为访问学者先后在香港大学微生物系www.med126.com、美国杜克大学癌症研究中心及美国科罗拉多大学医学中心工作4年。现担任湖南省病理生理学会副理事长兼秘书长，国际病理科学与临床杂志副主编及多家杂志编委；广州市“肿瘤学”重点扶持学科项目负责人。
先后主持国家自然基金3项、省部级科研课题4项，其他项目5余项，在Nature Medicine,Cell stem Cell,Cancer Res, Nucleic Acids Research, Oncogene, Cancer Letter等杂志发表科研论文110余篇，其中SCI收录论文40篇。获得2项省级成果，培养博士研究生8名，硕士研究生30名,在站博士后1人。
主要研究方向：恶性肿瘤发病和治疗耐受的分子机制
联系方式：E-mail:hezhimin2005@yahoo.com; Tel: 020-83492353
近3年以通讯作者发表的主要文章：
1. Weijia Zhang，Meilin Feng，Guopei Zheng，Ye Chen，Xuedong Wang，Bo Peng,Jiang Yin, Yanhui Yu, Zhimin He Chemoresistance to 5-fluorouracil induces epithelial- mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells. Biochem. Biophys. Res. Commun. 2012,417：679-685 (IF-2.595)
2. Guopei Zheng, Yan Xiong,, Sisi Yi,, Weijia Zhang, Bo Peng, Qiong Zhang, Zhimin He14-3-3r regulation by p53 mediates a chemotherapy response to 5-fluorouracil in MCF-7 breast cancer cells via Akt inactivation FEBS Lett. 2012, 586：163-168 (IF-3.601)
3. Bo Peng, Sisi Yi, Yixue Gu, Guopei Zheng and Zhimin He Purification and biochemical characterization of a novel protein—tongue cancer chemotherapy resistance-associated protein1 (TCRP1) Protein Expression and Purification. 2012，82:360-367 (IF-1.644)
4. Weijia Zhang, Wei Ding, Ye Chen, Meilin Feng, Yongmei Ouyang, Yanhui Yu, Zhimin He. Upregulation of breast cancer resistance protein plays a role in HER2-mediated chemoresistance through PI3K/Akt and nuclear factor-kappa B signaling pathways in MCF-7 breast cancer cells. Acta Biochim Biophys. Sin. 2011，43:647-53 (IF=1.547)
5. Yixue Gu, Shasha Fan, Yan Xiong, Bo Peng, Guopei Zheng, Yanhui Yu, Yongmei Ouyang,Zhimin He Cloning and functional characterization of TCRP1, a novel gene mediating resistance to www.med126.com cisplatin in an oral squamous cell carcinoma cell line . FEBS letters. 2011,585:881-887 (IF-3.601)
6. Gu Y, Fan S, Liu B, Zheng G, Yu Y, Ouyang Y, He Z. TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway. Mol Cell Biochem. 2011，357：107-113 (IF=2.168)
7. Xuedong Wang, Xingang Wu, Chengkun Wang, Weijia Zhang, Yanhui Yu, Yongmei ouyang, Zhimin He Transcriptional suppression of breast cancer resistance protein (BCRP) by wild-type p53 through NF-κB pathway in MCF-7 cells FEBS letters. 2010，584：3392-3397 (IF-3.601)
8. Guopei Zheng, Fang Peng, Renkui Ding, Yanhui Yu,Yongmei Ouyang, Zhuchu Chen, Zhiqiang Xiao, Zhimin He. Identification of proteins responsible for the multiple drug resistance in 5-Fluorouracil-induced breast cancer cell using proteomics analysis J. Cancer Res and Clinical Oncology 2010, 136(10):1477-88 (IF=2.485)
9. Guopei Zheng, Min Zhou, Xinrong Ou, Bo Peng, Yanhui Yu, Fangren Kong, Yongmei Ouyang, Zhimin He. Identification of CA Ⅸ as a contributor to pingyangmycin induced drug resistance in human tongue cancer cell. FEBS Journal. 2010，277:4506-4518 (JF=3.129)
10. Cheng-kun Wang, Jian-guo Cao, Bo Peng, Yi-xue Gu, Guo-pei Zheng, Zhi-min He. Inhibition of growth and motility of human A549 lung carcinoma cells by a recombined vascular basement membrane derived peptide. Cancer Letter 2010, 292: 261-268(IF=4.864)
11. Cheng-kun Wang, Jian-guo Cao, Jia-quan Qu, Bo Peng, Yi-xue Gu, Zhi-min He. Recombinant vascular basement membrane derived multifunctional peptide blocks endothelial www.med126.com cell angiogenesis & Neovascularization J. Cell Biochemisthy 2010, 111(2):453-60.(IF=3.422)
12. X. D.Wang, B. L. Wang, S. L. Ye, Y. Q. Liao, L. F. Wang and Z. M. He. Non-invasive foetal RHD genotyping via real-time PCR of foetal DNA from Chinese RhD-negative maternal plasma. Eur J Clin Invest 2009; 39 (7): 607–617 (IF 2.8 )
13. Janhui Yuan, Hui Lv, Bo Peng, Chengkun Wang, Yanhui Yu, Zhimin He. Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009，63：1103-1110 (IF=2.74)
