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医学免费论文:丹奥对非ST段抬高急性心肌梗死患者血液流变学及血浆内皮素和一氧化氮的影响
【摘要】 目的 观察奥扎格雷钠(丹奥)对非ST段抬高心肌梗死(NSTEMI)患者血液流变学指标、血浆内皮素和一氧化氮的影响，探讨其治疗价值 。方法 81例非ST段抬高的急性心肌梗死患者随机分为对照组和观察组，对照组使用单硝酸异山梨酯、低分子肝素、辛伐他汀，观察组在对照组治疗的基础上加用奥扎格雷钠，观察其临床疗效和血液流变学指标及血浆内皮素(endothelin, ET)和一氧化氮(nitrogen monoxidum, NO)的变化。结果 观察组疗效优于对照组(P<0.05)。治疗后观察组与对照组ET水平均较治疗前明显降低(P<0.05)，NO水平均较治疗前升高(P<0.05);且治疗后观察组ET、NO水平均较对照组改变明显(P<0.05)。治疗后观察组各项血液流变学指标均低于治疗前(P<0.05);对照组仅全血比黏度高切、血小板黏附率、纤维蛋白原低于治疗前(P<0.05);治疗后观察组各项指标均低于对照组(P<0.05)。结论 奥扎格雷钠能有效改善非ST段抬高急性心肌梗死患者的血液流变学指标和ET、NO水平，在常规治疗的基础上加用奥扎格雷钠能起到更好的治疗效果。
【关键词】 奥扎格雷钠;血液流变学;内皮素;一氧化氮;非ST段抬高心肌梗死
The effect of sodium ozagrel injection on hemorheology,
endothelin and nitrogen monoxidum of patients with nonST
segment elevation myocardial infarction医.学全.在.线网站www.med126.com
YUAN Yu, ZHANG Jinying, LIU Ping
1. The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052;2. Department of Cardiovascularology, the First Affiliated Hospital of XinxiangMedical University, Weihui 453100; 3. Department Two of Encephalopathy,
the Affiliated Hospital of Henan Traditional Chinese Medical College, Zhengzhou 450000, China
ABSTRACT: Objective To investigate the effect of sodium ozagrel injection on hemorheology, endothelin (ET) and nitrogen monoxidum (NO) of patients with nonST segment elevation myocardial infarction (NSEMI). Methods A total of 81 NSEMI patients were divided randomly into two groups: control group and experimental group. Isosorbide mononitrate, low molecular heparin and simvastatin were administered in the control group while sodium ozagrel was added to the experimental group apart from the abovementioned drugs. The clinical effect of sodium ozagrel was observed. The changes in the indexes of hemorheology, ET and NO were analyzed. Results The clinical effect was significantly better in the experimental group than in the control group (P<0.05). The level of ET was obviously lower after treatment than that in the experimental group and the control group before treatment (P<0.05). The level of NO was obviously higher after treatment than that in the experimental group and the control group before treatment (P<0.05). The changes of ET and NO in the experimental group posttreatment were more significant than those in the control group aftertreatment (P<0.05). The level of hemorheology index after treatment was lower than that before treatment in the experimental group (P<0.05). Highshear rate of whole blood viscosity, platelet adherence rate, and fibrin as hemorheology indexes were lower aftertreatment than those pretherapy in the control group (P<0.05). Conclusion Sodium ozagrel injection could affect hemorheology,ET and NO of patients with nonST segment elevation myocardial infarction. Thefore, the therapeutic efficacy can be better if sodium ozagrel is added to the conventional therapy.
KEY WORDS: sodium ozagrel injection; hemorheology; nitrogen monoxidum; nonST segment elevation myocardial infarction
