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本研究通过肢体缺血再灌注损伤的动物实验表明，阿加曲班可以有效改善肢体缺血再灌注后的血液流变学异常。分析原因主要有以下2点：(1)降低血浆P选择素和ICAM1浓度，减少白细胞粘附，从而减轻全身炎性反应。(2)直接灭活凝血酶(因子Ⅱa)的活性，避免进一步促进凝血作用的级联反应,防止微血栓形成。综上所述阿加曲班表现出对缺血再灌注损伤的保护作用。
【参考文献】
1 孙君志，苏全生.骨骼肌缺血再灌注损伤机制及其防治进展.四川体育科学,2006，12：4650.
2 戚伟，陈克俊，阚世廉，等.缺血后处理对大鼠骨骼肌缺血再灌注损伤的影响.中华手外科杂志,2009,25:121123.
3 张子彦.阿加曲班研究进展.国际内科学杂志,2007,34:483485.
4 Hitosugi M,Niwa M,Takatsu A.Changes in blood viscosity by heparin and argatroban. Thromb Res, 2001,104:371374.
5 符庆瑛,李著华,张艳青，等.兔肾缺血再灌注损伤时肠系膜微循环和血液流变性变化及PGI2的影响. 中国血液流变学杂志,2004,14:2529.
6 张钢，高珏琪.急性缺氧对大鼠肠系膜微循环白细胞流变学行为的影响.第三军医大学学报,2002,24:320322.
7 杨爱军.缺血再灌注损伤机制的研究进展.局解手术学杂志,1998,71817183.
8 Strieter RM, Kunkel SL. Acute lung injury: the role of cytokines in the elicitation of neutrophils. J Invest Med,1994,42:640651.
9 Senden NH, Jeunhomme TM, Heemskerk JW, et al. Factor Xa induces cytokine production and expressionof adhesion molecules by human umbilical vein endothelial cells. J Immunol, 1998,161:43184324.
10 Kaplanski G, Marin V, Fabrigoule M,et al.Thrombinactivated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule1 (ICAM1; CD54) and vascular cell adhesion molecule1 (VCAM1; CD106). Blood,1998,92:12591267医.学全.在.线网站www.med126.com.
11 Kaur J, Woodman RC, Ostrovsky L, et al. Selective recruitment of neutrophils and lymphocytes by thrombin: a role for NFkappaB. Am J Physiol Heart Circ Physiol,2001,281:H784H795.
12 Yamaguchi Y, Okabe K, Liang J,et al. Thrombin and factor Xa enhance neutrophil chemoattractant production after ischemia/reperfusionin the rat liver.J Surg Res,2000,92:96102.
13 Shinohara T, Suzuki K, Takada K,et al. Regulation of proteinaseactivated receptor 1 by inflammatory mediators in human vascular endothelial cells.Cytokine,2002,19: 6675.
14 罗承锋.阿加曲班的药理作用与临床应用.血栓与止血学,2007,13:185192.
15 Hitosugi M, Niwa M, Takatsu A. Changes in blood viscosity by heparin and argatroban. Thromb Res, 2001,104:371374.
