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医学免费论文:卡瓦脂质体纳米颗粒制备及其稳定性的研究
【摘要】 目的 制备包载卡瓦的脂质体纳米颗粒并研究其稳定性。方法 采用旋转薄膜蒸发法制备卡瓦纳米制剂，并对其形貌、大小等进行表征，考察纳米颗粒的稳定性。结果 卡瓦脂质体纳米颗粒平均粒径为(99.7±7.6)nm，多分散系数为0.321±0.011，Zeta电位为(-33.9±2.3)mV，包封率为(83.32±0.34)%;纳米溶液于4℃下放置60d，其纳米粒外观、粒径及包封率无明显变化，差异均无统计学意义(P>0.05)。结论 卡瓦脂质体纳米颗粒的包封率较高，粒径分布均匀，稳定性良好，为卡瓦的新剂型开发提供了实验依据。
【关键词】 卡瓦;脂质体;稳定性
Preparation and stability of kavaloaded lipid nanoparticlesZHENG Mingbin1,2, GONG Ping2,YANG Xuemei1,LI Shangde1,WU Xiren1,MEI Jun1 (1. Department of Chemistry,Guangdong Medical College,Dongguan 523808, China)Abstract:Objective To prepare the kavaloaded lipid nanoparticles from Piper methysticum and study their stability.Methods Kavaloaded lipid nanoparticles were prepared by rotaryfilm evaporation method, and their appearance, size and stability were observed.Results Mean size, polydispersity index,Zeta potential, and entrapment efficiency of kavaloaded lipid nanoparticles were 99.7 nm, 0.321,-33.9 mV, and 83.32%, respectively. Their appearance, size and entrapment efficiency showed no obvious changes after storage at 4℃ for 60 days. Conclusion The kavaloaded lipid nanoparticles have high entrapment efficiency, uniform particle size and good stability. The present study provides the experiment evidence for the development of novel dosage form of kava.
Key words: Piper methysticum (kava);lipid;stability医.学.全.在.线www.med126.com
植物提取物卡瓦油是从南太平洋岛屿盛产的胡椒科植物卡瓦(Piper methysticum)的干燥根中提取出来的植物生理活性成分。卡瓦油是一种良好的抗抑郁药，具有镇静催眠、抗真菌、抗血栓生成、抗疲劳、减肥、松弛肌肉等作用，在全球范围内受到广泛的关注[12]。但是卡瓦油的水溶性差，生物利用度低，目前尚没有研制出理想的卡瓦药物制剂，严重影响其广泛使用。脂质体纳米颗粒是极具潜力的给药载体，不仅能运载亲油性药物，还能运载亲水性药物，同时还可作为药物的储库，增加药物在皮肤的滞留量和滞留时间[34]。脂质体纳米颗粒制备简单，可多途径给药，易于规模化生产。有关卡瓦脂质体纳米颗粒制备及其稳定性研究目前尚未见有关报道，本文以卡瓦油为模型药物来考察脂质体纳米颗粒的制备及其物理稳定性。
