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医学免费论文:2型糖尿病血浆内脂素与糖脂代谢关系
【摘要】 目的:研究2型糖尿病(T2DM)患者血浆内脂素水平与糖脂代谢之间的关系。方法:选取48例初诊的T2DM患者(超重组27例，正常组21例)及32例健康对照，分别测量各组体重指数(BMI)、腰围、腰臀比、血压，并行空腹血浆内脂素、血脂、血糖、葡萄糖耐量(OGTT)及胰岛素释放试验(IRT)检测，计算胰岛素抵抗指数(HOMA-IR)及胰岛素分泌指数(HOMA-B)，并进行统计学分析比较。结果:T2DM患者血浆内脂素明显高于对照组(P<0.01)，而在超重组与正常组间则无显著差异。血浆内脂素浓度与空腹血糖FPG、餐后2 h血糖、胰岛素抵抗指数呈正相关(P均<0.01)，与胰岛素分泌指数(HOMA-B)呈负相关(P<0.01)。多元线性逐步回归分析表明，餐后2 h血糖是影响血浆内脂素的独立相关因素。结论:初诊T2DM患者血浆内脂素显著升高，可能是机体对体内血糖增高、胰岛功能受损所发生的一种代偿反应。
【关键词】 内脂素;糖尿病;肥胖;胰岛素抵抗
Study on the Relationship between Plasma Visfatin and Glucose Lipid Metabolism in Type 2 Diabetes MellitusWAN Chun-hui，CHEN Zhan-feng,ZHOU Meng Cadres Ward，2Divison of Medical Affairs，Taihe Hospital，Yunyang Medical College,Shiyan，Hubei 442000,China)Abstract: Objective To investigate the relationship between plasma visfatin level and glucose lipid metabolism in type 2 diabetes mellitus.Methods Forty-eight newly diagonosed patients with type 2 diabetes mellitus(T2DM) including 27 cases of overweight and 21 cases of normal weight and 32 healthy controls were enrolled.The indexes of BMI,WC,WRH,blood pressure were determined;the fasting plasma visfatin,lipid,glucose,OGTT and IRT were detected;insulin resistance index(HOMA-IR) and insulin secretion index(HOMA-B) were caculated and statistical analysis was conducted.Results The level of plasma visfatin in T2DM patients was significantly higher than that of control group(P<0.01),but there was no significant difference between overweight group and normal weight group.The level of plasma visfatin was positively correlated with fasting plasma glucose(FPG),postprandial 2 h blood glucose(2h PG),HOMA-IR(allP<0.01),and negatively correlated with HOMA-B(P<0.01).Multiple linear stepwise regression analysis showed that 2h PG was an independent related factor of plasma visfatin.Conclusion The increased plasma visfatin level in newly diagnosed T2DM patients may be a compensatory response against the increased blood glucose and impaired insulin function医.学.全.在.线www.med126.com.
Key words:Visfatin;Diabetes mellitus;Obesity;Insulin resistance
内脂素(visfatin)是一种主要由内脏脂肪组织分泌的具有胰岛素样效应的脂肪细胞因子,它通过作用于胰岛素受体(结合位点不同)减少肝糖的输出，刺激脂肪细胞及肌细胞对葡萄糖的利用而起到降糖作用。它的发现引发了人们对机体糖脂代谢平衡、脂肪细胞增殖分化的重新认识，它可能是糖尿病与肥胖的共同发病机制中的一个重要环节[1]。本研究目的在于探讨了血浆visfatin在T2DM人群中的变化以及与血糖及胰岛功能的意义。
