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医学免费论文:雷帕霉素对小鼠H22肝癌细胞生长增殖的影响
【摘要】 目的 探讨肝移植患者术后细菌感染的发生情况及相关因素。方法 回顾性分析我院2005年1月～2007年10月期间的肝移植术后患者56例次的临床资料，讨论细菌感染的发生情况，并对可能导致术后细菌感染的相关因素进行分析，筛选临床危险因素。结果 本组56例患者中29例(51.8%)发生细菌感染，感染部位以肺部(53.7%)为主，感染的菌种中G+菌(46.3%)主要为金葡菌及肠球菌，G-菌(53.7%)分布较分散。单因素及多因素logistic回归显示手术时间超过10h及呼吸机使用时间超过24h为手术后细菌感染的危险因素。结论 细菌感染是肝移植术后常见的并发症，临床应针对其可能的危险因素，采取提高手术技巧，促进呼吸功能恢复等手段，以减少术后细菌感染的发生。
【关键词】 肝移植;细菌感染;危险因素
Clinical analysis of bacterial infection in liver transplant recipients
GAO Rui, L Yi, LIU Chang, XIE Zhantao, ZHAI Chao, SHI Jianhua, WAN Zhen
1. Department of Hepatobiliary Surgery, the First Affiliated Hospital,Medical School of Xian Jiaotong University; 2. Faculty of Nursing,Medical School of Xian Jiaotong University, Xian 710061, China医.学全.在.线网站www.med126.com
ABSTRACT: Objective To explore the incidence and risk factors of bacterial infection after othtotopic liver transplantation (OLT). Methods Altogether 56 OLT recipients from January 2005 to October 2007 were included in the study. The incidents and the related variables of the infection were analyzed retrospectively. The related variables were evaluated using multivariate logistic regression model to identify the significant risk factors. Results Bacterial infection was confirmed in 29 recipients (51.8%). Among them, the lung infection was the most common site (53.7%). The Grampositive cocci were 46.3%, while the Gramnegative bacilli were 53.7%. The risk factors for bacterial infection included duration of the operation and detained respirator using. Conclusion Bacterial infection is a major complication following OLT. Surveillance for the risk factors, enhancement the skill of operation, and improving the recovery of respiratory function is the key to decreasing the incidence of bacterial infection after transplantation.
KEY WORDS: liver transplantation; bacterial infection; risk factor
肝移植手术已经在治疗终末期肝病方面取得了很大成功。但是，术后感染是肝移植术后常见的并发症，往往影响手术的预后，其发生率高达37.9%～66%[12]，其中细菌感染约占所有病原体感染的2/3[23]。了解肝移植术后细菌感染的种类及分布特点，对于肝移植术后感染的预防和护理有重要作用。现将我院肝移植科2005年1月～2007年10月施行的56例肝移植患者术后院内细菌感染情况和分离的所有菌株进行回顾性分析，以初步探讨术后细菌感染的相关危险因素。
