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医学论文范文:总胆红素与老年高血压患者低密度脂蛋白及白蛋白关系的探讨
【摘要】 目的 探讨血清总胆红素与老年高血压患者低密度脂蛋白、白蛋白的关系。方法 243例老年人,单纯高血压组60例,高血压肥胖组62例,对照组121例。测定3组的血清总胆红素、白蛋白、甘油三酯、高密度脂蛋白胆固醇、总胆固醇、低密度脂蛋白胆固醇,并对数据进行分析。结果 老年男性总胆红素高于老年女性,总胆红素与老年男性白蛋白及老年女性低密度脂蛋白胆固醇正相关。单纯高血压组老年男女总胆红素低于对照组,男性单纯高血压组与对照组比较差异有显著性意义;女性则差异无显著性意义。单纯高血压组老年人低密度脂蛋白胆固醇低于、高血压肥胖组老年人高于对照组,但差异无显著性意义。老年男性高血压组总胆红素与低密度脂蛋白胆固醇不相关,老年女性单纯高血压组总胆红素与低密度脂蛋白胆固醇正相关,与白蛋白不相关。结论 老年女性高血压患者总胆红素随低密度脂蛋白胆固醇水平的增高而增高,血清白蛋白与老年男性总胆红素有关联。性别及增龄对高血压患者总胆红素水平可能有一定影响。
【关键词】 高血压; 总胆红素; 低密度脂蛋白胆固醇; 白蛋白; 老年人
Relationship between serum total bilirubin and lowdensity lipoprotein,albumin in elderly patients with hypertension
SUN Yan,LIAO Shuping,LIU Yang
(Department of Medical Examination,Second Affiliated Hospital,Jinan Medical University,Shenzhen Guangdong 518020,China)
【Abstract】 Objective To study the relationship between serum total bilirubin(TBili) and lowdensity lipoprotein(LDLC),serum albumin in elderly patients with essential hypertension.Methods We selected 60 patients with essential hypertension only(hypertensionⅠgroup),62 overweight or obese senile people with essential hypertension(hypertensionⅡgroup)and 121 healthy control subjects(control group).The TBili,Alb,LDLC,TG,HDLC and TC of all cases were determined and statistical analyses were performed.Results The TBili was higher in elderly men than that in elderly women(P<0.05).Compared with control group,the male hypertensionⅠgroup showed lower TBili level(P<0.05).There was positive correlation between TBili and LDLC in elderly women(P<0.05) as well as serum albumin in elderly men(P<0.05).The TBili also had positive correlation with LDLC in female hypertensionⅠgroup(P<0.05).There was no correlation between TBili and LDLC in male hypertension subjects.Conclusion The level of TBili appears to increase along with rising of LDLC in elderly women with hypertension.There is a correlation between TBili and concentration of serum albumin in elderly male.Gender and aging may affect the TBili level in hypertension subjects.
【Key words】 hypertension;bilirubin;lowdensity lipoprotein;albumin;aged
高血压与动脉粥样硬化相关,而动脉粥样硬化的形成与低密度脂蛋白被氧化进而损伤血管内皮细胞有关[1]。文献报道胆红素的不同形式均具有抗氧化作用,能阻止低密度脂蛋白被氧化,防止动脉粥样硬化的发生[2],当胆红素等抗氧化剂被消耗呈低水平时,低密度脂蛋白的氧化修饰增加[3]。白蛋白也是内源性抗氧化剂,可防止氧自由基对膜脂质等的过氧化作用[4],高血压患者总胆红素与低密度脂蛋白胆固醇负相关[5]。老年阶段常见高血压,我们聚焦于老年高血压患者,观察其血清总胆红素、低密度脂蛋白胆固醇及白蛋白水平及其相互关系医学 全在.线提供www.med126.com。
1 资料与方法
