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医学论文范文:2007-2009年我院3种非发酵革兰阴性杆菌药物敏感性调查
【摘要】 目的:了解鲍曼不动杆菌、铜绿假单胞菌、嗜麦芽窄食单胞菌对常用抗菌药物的耐药性。方法:KB法对分离菌株进行抗菌药物药敏试验。结果:分别分离铜绿假单胞菌、鲍曼不动杆菌、嗜麦芽窄食单胞菌745、367和25株。鲍曼不动杆菌耐药率达90%(头孢哌酮/舒巴坦例外，18%)。铜绿假单胞菌对复方新诺明、头孢噻肟、庆大霉素、哌拉西林耐药率80%。嗜麦芽窄食单胞菌分离率不高，对环丙沙星、头孢哌酮/舒巴坦、复方新诺明耐药率小于35%，对头孢噻肟、氨曲南、哌拉西林耐药率均超过80%。多重耐药菌株数分离率呈上升趋势，2009年58.54%菌株对5种抗生素均耐药。结论:3种非发酵糖革兰阴性杆菌耐药性严重，临床应根据药敏结果合理使用抗生素。
【关键词】 院内感染;非发酵糖革兰阴性杆菌;多重耐药
Drug Susceptibility of Three Nonfermentation Gram Negative Bacilli in 2007-2009 HOU Lingli1,2,TAO Jianshu1,ZHANG Jicai2,LV Jun2,YANG Hongwei2^,FENG Jing2 (Department of Clinical Laboratory,1Guiyang Medical College,Guiyang,Guizhou 550000;2Taihe Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China)
Abstract: Objective To analyze the drug susceptibility of Acinetobacter baumannii,Pseudomonas aeruginosa and Stenotrophomonas maltophilia to clinical common antibacterials.Methods The drug susceptibility of isolated strains were determined with KB method.Results A total of 745,367 and 25 strains of Acinetobacter baumannii,Pseudomonasaeruginosa and Stenotrophomonas maltophilia were isolated,respectively.The resistance rate of Acinetobacter baumannii was high to 90%(exclude cefoperazone/sulbactam,18%).The resistance rate of Pseudomonas aeruginosa to trimethoprimsulfamethoxazole,cefotaxime,gentamycin,piperacillin were about 80%.The isolating rate of Stenotrophomonas maltophilia was low.The drug resistant rate to ciprofloxacin,cefoperazone/sulbactam,trimethoprimsulfamethoxazole was less than 35% and to cefotaxime,aztreonam,piperacillin was more than 80%.The isolating rate of multidrug resistant strains showed an increasing tendency,58.54% strains were drug resistant to 5 kind antibiotics in 2009.Conclusion The drugresistance status of three nosocomial gram negative bacilli was serious,the selection of antibiotics should base on the drug susceptibility results医.学.全.在.线www.med126.com.
Key words:Nosocomial infections;Nonfermentation gram negative bacilli;Multidrug resistance
非发酵糖革兰阴性杆菌引起的医院感染及其多重耐药性日益严重，特别是对亚胺培南耐药的鲍曼不动杆菌、铜绿假单胞菌等所致的严重感染已成为临床抗感染治疗难点之一。因此监测非发酵糖革兰阴性杆菌感染及其耐药性变化趋势，对于有效预防和治疗不动杆菌感染有重要意义。本研究回顾性分析了我院3种非发酵糖革兰阴性杆菌对抗菌药物的耐药状况，旨在指导临床科学用药。
