医学论文范文:内皮素1和血管内皮生长因子及缺氧诱导因子1在门脉高压性胃病中的作用

来源：本站原创更新：2013-9-5 论文投稿平台

医学论文范文:内皮素1和血管内皮生长因子及缺氧诱导因子1在门脉高压性胃病中的作用

【摘要】目的探讨患者胃黏膜是否有内皮素1(ET1)、血管内皮生长因子(VEGF)和缺氧诱导因子1(HIF1)在门脉高压性胃病(PHG)血流动力学调节中的意义。方法分别采取PHG、PHT无PHG、正常对照患者胃黏膜标本用免疫组织化学方法分别检测ET1、VEGF和HIF1在胃黏膜中的表达。同时测定3组患者的门静脉血流量(portal venous flow,PVF)和脾静脉血流量(spleen venous flow,SVF)。结果 PHG积分与食管静脉曲张程度无相关性(HC=4.782，P>0.05)。PHG组PVF和SVF水平明显高于正常对照组(P<0.05)。PHG组胃黏膜中ET1、VEGF、HIF1的阳性面积高于正常对照组(P<0.05)。ET1、VEGF、HIF与PHG积分呈正相关(H分别为10.592、10.614、9.852，P<0.05)。PHG组患者HIF1阳性表达和VEGF的阳性表达之呈直线相关(Pearson相关数为0.842，P<0.01)。结论 ET1、VEGF和HIF1与PHG的发生发展有相关性。

【关键词】内皮素1;血管内皮生长因子;缺氧诱导因子1;门静脉高压性胃病;免疫组化

Endothelin1，vascular endothelial growth factor and hypoxia inducible factor1 in patients with portal hypertensive gastropathy LI Shujuan,SHAO Shixiang,GENG Guoyu,et al.The Fifth Hospital of Shijiazhuang, Shijiazhuang 050021,China

【Abstract】 Objective To investigate the significance of endothelin1(ET1),vascular endothelial growth factor (VEGF) and hypoxiainducible factor 1 (HIF1)in patients with portal hypertensive gastropathy(PHG).Methods The specimens of gastric mucosa were divided into three groups,patients with PHG group, PHT without PHG group and control group.The specimens were detected by immunohistochemical methods for the levels of ET1,VEGF and HIF1 respectvely.At the same time,the portal vein blood flow(PVF)and splenic blood flow(SVF)were detected in the three groups.Results PHG scoring was not related with the degree of esophageal varices(P>0.05). The levels of PVF and SVF in PHG group were significantly higher than those of control group(P<0.05). The positive area of ET1, VEGF and HIF1in PHG group was significantly higher than that of control group (P<0.05). The levels of ET1, VEGF,HIF1 were positively correlated with PHG scoring(P<0.05). The positive expression of HIF1in PHG group showed a straight line correlation with the positive expression of VEGF (Pearson correlation coefficient:0.842,P<0.01).Conclusion The levels of ET1,VEGF and HIF1 are correlated with the pathogenesis and development of PHG.

【Key words】 endothelin1;vascular endothelial growth factor;hypoxiainducible factor1;portal hypertensive gastropathy; immunohistochemistry

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