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c┐myc基因蛋白在外阴白斑和外阴鳞癌中的表达及临床意义
作者：樊 昕 ，余春艳，赵一岭
关键词: 原癌基因蛋白质c-myc类;外阴白斑;外阴肿瘤;免疫组织化学
摘 要:目的 研究c-myc基因蛋白在外阴白斑和外阴鳞癌中的表达. 方法 采用SABC免疫组化法，对71例外阴白斑和21例外阴鳞癌标本进行c-myc基因蛋白检测. 结果 c-myc基因蛋白在正常组织中主要分布在细胞核，外阴白斑各型和鳞癌组织中主要分布在细胞浆.外阴白斑各型与鳞癌组相比较，经χ2 检验，正常组(χ2 =11.072，P<0.05)、增生组(χ2 =5.692，P<0.05)、硬化萎缩组(χ2 =16.488，P<0.05)、混合组(χ2 =6.497，P<0.05)和不典型增生组(χ2 =1.072，P>0.05).21例鳞癌标本，Ⅰ级，Ⅱ级，Ⅲ级中c-myc蛋白的阳性率分别为100.0%(9/9)，85.7%(6/7)，60.0%(3/5). 结论 c-myc基因蛋白的表达和分布与外阴白斑分型有关，外阴鳞癌和不典型增生组织中表达阳性率明显高于外阴白斑各型，c-myc基因蛋白的过度表达可能与外阴鳞癌的发生有一定的关系.
Clinical significance and expression of c┐myc gene protein in genitalia leukoplakia and squamous cell carcinoma of vulva
FAN Xin，YU Chun-Yan，ZHAO Yi-Ling
Department of Dermatology，Tangdu Hospital，Xi`an710038，Department of Pathology，Faculty of Preclinical Medicine，Fourth Military Medical U-niversity，Xi'an710033，China
Keywords:proto-oncogene proteins c-myc;leukoplakia vul-vae;vulvar neoplasms;immunohistochemistry
Abstract:AIM To study the expression of c-myc gene pro-tein in genitalia leukoplakia and squamous cell carcinoma of vulva.METHODS The genitalia leukoplakia in71cases and squamous cell carcinoma in21cases were detected with c-myc gene protein by SABC immunohistochemical technique.RESULTS c-myc gene protein was mainly distributed in the cell nucleus in normal tissue and in the cell cytoplasm in hy-perplasia type，atypical hyperplasia and squamous cell carci-noma.χ2 test showed significant difference between the squa-mous cell carcinoma and the other types of benign pathologi-cal changes except the type of atypical hyperplasia(χ2 =1.072，P>0.05):Normal group(χ2 =11.027，P<0.05);hyperplasia type group(χ2 =5.692，P<0.05);sclerotic at-rophic type group(χ2 =16.488，P<0.05);mixed type group(χ2 =6.497，P<0.05).The positive rates of c-myc gene pro-tein in the different stages of squamous cell carcinoma group(21cases)were100.0%(9/9)in stage I，85.7%(6/7)in stageⅡ，and60.0%(3/5)in stageⅢrepectively.CONCLUSION Expression and distribution of c-myc gene protein might be correlated with the types of genitalia leuko-plakia.c-myc gene protein has a higher expression rate in squamous cell carcinoma of vulva and atypical hyperplasia than that in various types of genitalia leukoplakia.These data suggest that overexpression of c-myc gene protein may be re-lated to the oncogenesis of squamous cell carcinoma of vulva.
